منابع مشابه
Sticking it out with tight junctions
f patience is a virtue, then Daniel Goodenough and Bruce Stevenson earned their wings in the pursuit of the first tight junction protein. Stevenson spent seven years as a graduate student with Goodenough (Harvard Medical School, Boston, MA) before the two worked out the conditions to purify fragile tight junction–enriched preparations from mouse liver (Stevenson and Goodenough, 1984). It was en...
متن کاملZOning out Tight Junctions
The tight junction is an intricate seal between adjoining epithelial cells that also separates the apical and basolateral membranes within these cells. A paper in this issue of Cell by Umeda et al. (2006) demonstrates that loss of the ZO scaffolding proteins prevents the formation of tight junctions but surprisingly does not perturb apico-basal polarity.
متن کاملEpithelium: sticking it out, together.
SOME CELLS LIVE WITHIN A COMMUNITY of neighboring cells, restricted in time and space, most prominently interacting with cells of similar functions. Some cells live within fixed positions, surrounded on all sides by a loose forest of matrix proteins. Some cells live as nomads, wandering throughout the body, responding to needs as they arise. Each cell is part of an elaborate orchestra, coordina...
متن کاملTight Junctions
Epithelial cells cover the body (e.g. skin), cavities (e.g. stomach, uterus, bladder) and ducts (e.g. renal tubules, intestine) of multicellular organisms, and thus constitute the frontier between the individual and the external milieu. In areas that withstand strong mechanical or chemical stress (e.g. skin, esophagus, cornea, vagina) epithelia are stratified, whereas in the rest of the body, t...
متن کاملTight junctions
part of my lab in that direction with work on human embryonic stem cells which, as we have come to learn, show aberrant epigenetic regulation. There is a lot to learn from this much needed human model. What do you enjoy most about science? The challenge, the discovery, and the people. In this profession, one meets some of the brightest (and most eccentric) minds on Earth. Although I dislike air...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1716fta1